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. 2022 Aug 2;66(9):e02405-21. doi: 10.1128/aac.02405-21

TABLE 2.

Cytomegalovirus mutations associated with maribavir and ganciclovir resistancea

UL97 genotype Fold increase in EC50 or IC50
Source or reference
Maribavir Ganciclovir
V353A 12−27 53, 59
L397R >200 53
T409M 78−90 31, 53, 56, 57
H411L 69 53
H411N 9 53
H411Y 12−20 53, 56, 57
L337M 3.4−7.2 55
C480F 224 2.3 56
F342Y 4.5 6.0 57
F342Y, H411Y 56 5.9 57
W153R 1.7 59
L193F 2.6 59
A269T 2 59
V353E 2.1 59
L426E 2.2 59
E22stop 2 59
W362stop 2.2 59
218delC 2.5 59
301−311del 3.1 59
a

EC50, 50% effective concentration; IC50, 50% inhibitory concentration.