TABLE 2.
UL97 genotype | Fold increase in EC50 or IC50 |
Source or reference | |
---|---|---|---|
Maribavir | Ganciclovir | ||
V353A | 12−27 | 53, 59 | |
L397R | >200 | 53 | |
T409M | 78−90 | 31, 53, 56, 57 | |
H411L | 69 | 53 | |
H411N | 9 | 53 | |
H411Y | 12−20 | 53, 56, 57 | |
L337M | 3.4−7.2 | 55 | |
C480F | 224 | 2.3 | 56 |
F342Y | 4.5 | 6.0 | 57 |
F342Y, H411Y | 56 | 5.9 | 57 |
W153R | 1.7 | 59 | |
L193F | 2.6 | 59 | |
A269T | 2 | 59 | |
V353E | 2.1 | 59 | |
L426E | 2.2 | 59 | |
E22stop | 2 | 59 | |
W362stop | 2.2 | 59 | |
218delC | 2.5 | 59 | |
301−311del | 3.1 | 59 |
EC50, 50% effective concentration; IC50, 50% inhibitory concentration.