TABLE 3.
ET Onset Age and Parkinsonian Features of 58 ET Cases Stratified into 10 Categories of Lewy Pathology
| Category | Location of LP | N | Age at Onset of ET Sx/Sgn (Years) | Years From ET Onset to Death (Years) | Parkinsonian Features | Age at Onset of Parkinsonian Sx/Sgn (Including Rest Tremor) (Years) | Years From Onset of ET Sx/Sgn to Parkinsonian Features (Including Rest Tremor) | Clinical Diagnosis With Respect to ET and PD |
|---|---|---|---|---|---|---|---|---|
| 1 | NSPD 1 | 1 | 41.0 | 50.0 | 0 (0.0) | NA | NA | ET: 1 (100) |
| 2 | NSPD 2 | 4 | 72.3 ± 4.5 | 21.3 ± 5.3 | 0 (0.0) | NA | NA | ET: 4 (100) |
| 3 | NSPD 3 | 8 | 42.1 ± 20.7 | 44.4 ± 16.8 | 4 (50.0) | 81.5 ± 6.1 | 43.9 ± 22.2 | ET: 5 (62.5) |
| ET-ETpPD: 2 (25.0) | ||||||||
| ET-ETPD: 1 (12.5) | ||||||||
| 4 | NSPD 4 | 5 | 52.6 ± 22.5 | 33.4 ± 24.6 | 3 (60.0) | 82.0 ± 10.2 | 24.7 ± 14.7 | ET: 3 (60.0) |
| ET-ETpPD: 1 (20.0) | ||||||||
| ET-ETPD: 1 (20.0) | ||||||||
| 5 | NSPD 5 | 8 | 52.3 ± 23.3 | 38.9 ± 21.9 | 3 (37.5) | 85.7 ± 8.1 | 35.0 ± 38.2 | ET: 5 (62.5) |
| ET-ETpPD: 1 (12.5) | ||||||||
| ET-ETPD: 2 (25.0) | ||||||||
| 6 | NSPD 6 | 7 | 40.3 ± 25.0 | 48.7 ± 24.0 | 4 (57.1) | 81.8 ± 5.1 | 50.3 ± 19.5 | ET: 3 (42.9) |
| ET-ETpPD: 2 (28.6) | ||||||||
| ET-ETPD: 2 (28.6) | ||||||||
| 7 | Amygdala predominant | 10 | 45.4 ± 21.4 | 43.1 ± 21.5 | 1 (10.0) | 83.0 | 67.0 | ET: 9 (90.0) |
| ET-ETpPD: 1 (10.0) | ||||||||
| ET-ETPD: 0 (0.0) | ||||||||
| 8 | LC only | 2 | 29.0 ± 22.6 | 51.5 ± 24.8 | 0 (0.0) | NA | NA | ET: 2 (100) |
| ET-ETpPD: 0 (0.0) | ||||||||
| ET-ETPD: 0 (0.0) | ||||||||
| 9 | ≥2 regions not fitting Braak staging | 11 | 47.0 ± 28.2 | 42.8 ± 28.5 | 1 (9.1) | 88.0 | 18.0 | ET: 10 (90.9) |
| ET-ETpPD: 1 (9.1) | ||||||||
| ET-ETPD: 0 (0.0) | ||||||||
| 10 | OB only | 2 | 45.5 ± 34.7 | 46.5 ± 24.8 | 0 (0.0) | NA | NA | ET: 2 (100) |
| ET-ETpPD: 0 (0.0) | ||||||||
| ET-ETPD: 0 (0.0) | ||||||||
| Entire cohort | 58 | 47.4 ± 23.2 | 41.5 ± 22.0 | 16 (27.6) | 82.9 ± 6.3 | 40.0 ± 23.7 | ET: 44 (75.9) | |
| ET-ETpPD: 8 (13.8) | ||||||||
| ET-ETPD: 6 (10.3) |
All values are mean ± standard deviation or number (percentage) unless otherwise specified.
ET, essential tremor; ET-ETpPD, essential tremor and then possible PD; ET-ETPD, essential tremor and then PD; LC, locus coeruleus; LP, Lewy pathology; NA, not applicable; NSPD, neuropathological stage of Parkinson disease; OB, olfactory bulb; sx/sgn, symptoms and signs.