Table 1.
The effect of ROS scavengers on the activation of apoptosis in two distinct cancer cell lines by delphinidin.
| Cancer Cell Line | Dose | Apoptosis (folds) | Effect of Scavengers |
|---|---|---|---|
| PC3 | Untreated | – | – |
| Delphinidin (50 µM) | 2.49 | – | |
| Thiourea | 1.78 | 28.51 | |
| Catalase | 2.13 | 14.45 | |
| SOD | 1.97 | 20.88 | |
| MDA-MB-231 | Untreated | – | – |
| Delphinidin (50 µM) | 3.32 | – | |
| Thiourea | 2.17 | 34.63 | |
| Catalase | 2.69 | 18.97 | |
| SOD | 2.51 | 24.39 |
Along with delphinidin, cancer cells were co-incubated with multiple ROS scavengers, including TU, (100 µM Thiourea); Cat, (100 mg/mL catalase); and SOD, (100 mg/mL superoxide dismutase); The effect on apoptosis was determined using Histone/DNA ELISA as described in the “Methods” section. Apoptosis (folds) represents the increase in apoptosis in comparison to the untreated control.