Table 3.
Correlations for young adults are presented below the diagonal. Correlations for middle-aged adults are above the diagonal. Correlation and level are provided for FKBP5-2, a three-indicator measure of cardiometabolic risk (CMR), the Framingham cardiometabolic 10-year risk score (FCMR10), four methylation-based indices of extrinsic accelerated ageing (AA), FKBP5-PC1, five cell-types, as well as covariates of sex and age (N = 449 for young adults; N = 469 for middle-aged adults). Medians, Means and SDs are shown below the correlations.
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. FKBP5-2 | – | .04 | −.23** | −.34** | −.25** | −.20** | −.17** | .12** | −.04 | .07 | −.09† | −.23** | −.14** | −.23** | −.29** |
| 2. CMR | −.11* | – | .46** | .10* | .12* | .15** | −.04 | −.12* | −.07 | −.13** | −.02 | −.04 | .05 | −.05 | −.04 |
| 3. FCMR10 | −.13** | .55** | – | .14** | .09† | .13* | .32** | −.17** | −.01 | −.19** | .07 | −.02 | .12* | .44** | .48** |
| 4. Hannum-AA | −.29** | .12** | .15** | – | .42** | .46** | .24** | −.22** | −.16** | −.40** | .15** | .04 | .26** | .29** | −.01 |
| 5. Horvath-AA | −.24** | .14** | .14** | .36** | – | .35** | .02 | −.06 | .03 | −.08 | .13* | .10* | .00 | .12* | −.02 |
| 6. PhenoAge-AA | −.17** | .19** | .08 | .52** | .36** | – | .34** | −.33** | −.27** | −.23** | −.06 | −.02 | .20** | −.00 | −.02 |
| 7. Grim-AA | −.14** | .00 | .27** | .24** | .01 | .30** | – | −.21** | −.12** | −.14** | −.08 | −.12** | .19** | .35** | .01 |
| 8. PC1 | .34** | −.11* | −.07 | −.34** | −.15** | −.34** | −.19** | – | .58** | .37** | .37** | .42** | −.36** | −.06 | −.14** |
| 9. CD8T | −.06 | −.11* | .03 | −.30** | .09 | −.27** | −.17** | .62** | – | −.07 | .33** | −.08† | −.14** | .07 | −.01 |
| 10. CD4T | .15** | −.01 | −.04 | −.45** | −.11* | −.39** | −.18** | .44** | .15** | – | −.13** | .18** | −.50** | −.13** | −.15** |
| 11. NK | −.07 | −.01 | .07 | .16** | .09 | −.01 | −.06 | .33** | .21** | −.12* | – | −.06 | −.04 | .08 | .13** |
| 12. Bcell | .15** | −.04 | −.08 | −.23** | −.10* | −.22** | −.14** | .50** | .14* | .36** | −.05 | – | −.24** | .00 | .01 |
| 13. Mono | −.12* | .03 | .12* | .36** | .12* | .28** | .17** | −.29** | −.17** | −.51** | .06 | −.31** | – | .21** | .06 |
| 14. Sex | −.13** | −.02 | .45** | .18** | .17** | −.12* | .26** | .08 | .18** | −.15** | .25** | .05 | .18** | – | .07 |
| 15. Age | −.05 | .01 | .08 | .01 | −.00 | .03 | −.01 | −.03 | −.04 | −.01 | −.02 | −.01 | −.00 | −.05 | – |
| Young adults | |||||||||||||||
| Median | .51 | −.22 | .02 | .28 | −.01 | −.27 | −.18 | −.06 | .09 | .15 | .00 | .04 | .05 | .00 | 29.00 |
| Mean | .51 | .04 | .02 | .00 | .00 | .00 | .00 | .00 | 1.00 | .15 | .01 | .04 | .06 | .38 | 28.67 |
| SD | .03 | 2.06 | .01 | 3.41 | 4.03 | 5.43 | 4.22 | 1.00 | .05 | .05 | .02 | .03 | .02 | .49 | .79 |
| Middle-aged | |||||||||||||||
| Median | .42 | .01 | .21 | .03 | −.32 | −.18 | −1.00 | −.03 | .11 | .12 | .00 | .02 | .06 | .00 | 56.17 |
| Mean | .42 | −.01 | .27 | −.01 | .03 | −.06 | −.04 | .00 | .12 | .13 | .01 | .03 | .06 | .26 | 57.21 |
| SD | .03 | 1.83 | 1.95 | 3.65 | 4.41 | 4.82 | 4.66 | 1.00 | .05 | .06 | .03 | .05 | .03 | .44 | 6.75 |
CMR = Cardiometabolic Risk; FCMR10 = Framingham Cardiometabolic Risk 10 years; PC1 = FKBP5-PC1.
† p < 0.1, * p < 0.05, ** p < 0.01.