Table 2.
Characteristics of the studies on the association of NR3C1 methylation in newborn infants and perinatal condition.
| Publication Author, year |
Study population | Sample size | Collected tissue for methylation | Collection time | Measures | Measuring instruments |
|---|---|---|---|---|---|---|
| Oberlander et al., 2008 [26] | mother-baby dyad | 82 | Maternal peripheral blood Cord blood Baby saliva (basal cortisol) |
3rd trimester At birth 3 mo. |
Maternal depression and anxiety | HAM-D HAM-A EPDS PSI |
| Mulligan et al., 2012 [27] | mother-baby dyad | 25 | Maternal peripheral blood Cord blood |
Labour At birth |
Maternal financial, psychosocial and war stress in prenatal care | Researcher’s questionnaires |
| Hompes et al., 2013 [28] | mother-baby dyad | 83 | Cord blood Maternal saliva (cortisol) |
At birth Quarterly |
Maternal depression Maternal anxiety Pregnancy related anxiety Mother-foetal attachment |
EDS STAI PRAQ MFAS |
| Non et al., 2014 [44] | mother-baby dyad | 58 | Cord blood | At birth | Depression/anxiety during pregnancy | Self-report in childbirth form |
| Braithwaite et al., 2015 [45] | mother-baby dyad | 57 | Buccal swab Maternal saliva (cortisol) |
2 mo. Pregnancy |
Prenatal maternal depression | EPDS |
| Mansell et al., 2016 [46] | mother-baby dyad | 481 | Cord blood | At birth | Maternal stress Maternal depression and anxiety |
PSS EPDS |
| Kantake et al., 2014 [34] | term newborn preterm newborn |
20 20 |
Cord blood Peripheral blood |
At birth Day 4 |
NICU admission | |
| Giarraputo et al., 2017 [36] | preterm <1500 g | 63 | Buccal swab | Pre-discharge | NICU admission | NTISS |
| Kantake et al., 2018 [47] | preterm with CLD | 19 | Cord blood Peripheral blood |
At birth 1 and 2 mo. |
NICU admission | |
| Burris et al., 2013 [48] | term newborn from healthy mothers | 219 | Cord blood | At birth | Foetal growth and birth weight |
CLD – chronic lung disease; EDS – Edinburgh Depression Scale; EPDS – Edinburgh Postnatal Depression Scale; MFAS – Maternal-Foetal Attachment Scale; NTISS – Neonatal Therapeutic Intervention Scoring System; PRAQ – Pregnancy Related Anxiety Questionnaire; PSI – Parent Stress Index; PSS – Perceived Stress Scale; STAI – State Trait Anxiety Inventory; NICU – Neonatal Intensive Care Unit