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Selectivity of compounds 30, 42, 58 and 75 (see red box) against (a-b) two bacterial DNA adenine MTases (Escherichia coli Dam and Caulobactor crescentus CcrM), (c-e) three mammalian DNA cytosine MTases (human DNMT1, mouse Dnmt3a-3L and Dnmt3b-3L), and (f-i) four human RNA adenine MTases (MettL3-MettL14, MettL5-Trm112, MettL16 and PCIF1). The reaction condition and substrate for each enzyme are indicated.
