FIGURE 1.

Chronic obstructive pulmonary disease subgroups without clear treatment implications. The figure shows the subgroups with clear prognostic implications for patients that are clinically relevant, but where therapeutic strategies are as yet unclear. The directions of the arrows indicate the probable direction of the association, e.g. patients with more frequent exacerbations are less likely to survive. The direction of association of bacterial colonisation and bronchiectasis is not clear; thus, a bidirectional arrow is shown.