Table 5:
Individual CPIP components at 12 months CG A
| Cohort | Type of Component | N (%) survival without CPIP at 12 months CGAa | N (%) without CPIP in survivors at 12 months CGAa | ||||
|---|---|---|---|---|---|---|---|
| Placebo | rhCC10 | P-value | Placebo | rhCC10 | P-value | ||
| Cohort 1 | N | 22 | 22 | 22 | 20 | ||
| None | 1 (5) | 1 (5) | >0.9 | 1 (5) | 1 (5) | >0.9 | |
| No CPIP-DV (Medical/ER visits) | 8 (36) | 2/21 (10) | 0.04 | 8 (36) | 2/19 (11) | 0.055 | |
| No CPIP-RH (Respiratory hospitalizations) | 20 (91) | 12 (55) | 0.007 | 20 (91) | 12 (60) | 0.02 | |
| No CPIP-SS (Respiratory Symptoms) | 2/22 (9) | 3/21 (14) | 0.6 | 2 (9) | 3/19 (16) | 0.5 | |
| No CPIP-RM (Respiratory Medications) | 10 (45) | 7/21 (33) | 0.4 | 10 (45) | 7/19 (37) | 0.6 | |
| Cohort 2 | N | 21 | 23 | 19 | 18 | ||
| None | 3 (14) | 3 (13) | 0.9 | 3 (16) | 3 (17) | 0.9 | |
| No CPIP-DV (Medical/ER visits) | 6 (29) | 6/22 (27) | 0.9 | 6 (32) | 6/17 (35) | 0.8 | |
| No CPIP-RH | |||||||
| (Respiratory re-hospitalizations) | 11 (52) | 10/22 (45) | 0.6 | 11 (58) | 10/17 (59) | >0.9 | |
| No CPIP-SS (Respiratory Symptoms) | 6 (29) | 5/22 (23) | 0.7 | 6 (32) | 5/17 (29) | 0.9 | |
| No CPIP-RM (Respiratory Medications) | 6 (29) | 5/22 (23) | 0.7 | 6 (32) | 5/17 (29) | 0.9 | |
a
: No imputation for missing data; denominators reflect actual numbers of patients for whom data were collected at this time point.
CPIP – chronic pulmonary insufficiency of the prematurity; DV – unscheduled doctor and emergency room visits, RH – respiratory hospitalizations, SS – signs/symptoms respiratory disease, RM – respiratory medications including oxygen