TABLE 1.

Two‐sample Mendelian randomization estimates for the relationship between alcohol consumption and colorectal cancer risk

Exposure	SNPs	MR method	OR (95% CI)	P Effect	P Heterogeneity	P Intercept
Main analysis
Drinks per week	84	IVW	1.79 (1.23, 2.61)	.003	1.39 × 10−4
		MR Egger	2.03 (0.93, 4.43)	.080	1.10 × 10−4	.717
		Weighted median	1.49 (0.91, 2.43)	.112
		Simple mode	1.55 (0.44, 5.50)	.498
		Weighted mode	1.19 (0.59, 2.41)	.635
		MR‐PRESSO	1.93 (1.36, 2.73)	3.90 × 10−4
Alcohol use disorder	18	IVW	1.33 (0.95, 1.85)	.093	.110
		MR Egger	0.90 (0.49, 1.68)	.753	.155	.174
		Weighted median	1.13 (0.76, 1.69)	.541
		Simple mode	1.62 (0.72, 3.65)	.257
		Weighted mode	1.04 (0.65, 1.65)	.878
		MR‐PRESSO	1.33 (0.95, 1.85)	.111
Problematic alcohol use	24	IVW	1.53 (1.02, 2.29)	.040	.002
		MR Egger	0.91 (0.45, 1.83)	.787	.006	.093
		Weighted median	1.07 (0.69, 1.65)	.759
		Simple mode	0.86 (0.35, 2.09)	.736
		Weighted mode	0.95 (0.60, 1.50)	.819
		MR‐PRESSO	1.40 (0.99, 1.98)	.071
Sensitivity analysis
Drinks per week	63	IVW	1.77 (1.17, 2.69)	.007	.005
		MR Egger	1.66 (0.75, 3.66)	.216	.004	.846
		Weighted median	1.53 (0.90, 2.60)	.114
		Simple mode	2.25 (0.58, 8.69)	.243
		Weighted mode	1.30 (0.63, 2.68)	.472
		MR‐PRESSO	1.96 (1.36, 2.83)	6.38 × 10−4
Alcohol use disorder	13	IVW	1.31 (0.86, 1.98)	.206	.063
		MR Egger	0.95 (0.46, 1.98)	.901	.072	.325
		Weighted median	1.15 (0.74, 1.78)	.546
		Simple mode	1.43 (0.57, 3.56)	.461
		Weighted mode	1.06 (0.64, 1.76)	.827
		MR‐PRESSO	1.31 (0.86, 1.98)	.230
Problematic alcohol use	17	IVW	1.27 (0.88, 1.81)	.199	.271
		MR Egger	0.99 (0.55, 1.79)	.972	.279	.321
		Weighted median	1.08 (0.69, 1.69)	.745
		Simple mode	0.87 (0.33, 2.30)	.776
		Weighted mode	1.01 (0.63, 1.64)	.955
		MR‐PRESSO	1.27 (0.88, 1.81)	.218