TABLE 2.

Two‐sample Mendelian randomization estimates for alcohol‐related CpG sites and colorectal cancer risk

CpG sites	Chr	Position	Nearest gene (s)	Method	SNP	OR (95% CI)	P value
cg10045354	11	111 169 427	COLCA2, COLCA1	Wald ratio	1	1.67 (1.47, 1.89)	3.54 × 10 −16
cg05593667	6	35 490 744	–	Wald ratio	1	0.89 (0.84, 0.95)	1.25 × 10 −4
cg03575969	10	82 172 508	STARD10, ARAP1	Wald ratio	1	1.17 (1.05, 1.31)	5.91 × 10−3
cg22871253	6	159 238 744	EZR	Wald ratio	1	1.12 (1.02, 1.24)	2.08 × 10−2
cg12662084	6	17 809 126	KIF13A	Wald ratio	1	0.91 (0.84, 0.99)	2.31 × 10−2
cg26312998	6	43 337 775	ZNF318	Wald ratio	1	1.05 (1.01, 1.10)	2.80 × 10−2
cg17390562	6	159 238 463	EZR	Wald ratio	1	1.10 (1.01, 1.19)	3.48 × 10−2
cg10456541	2	8 721 512	–	Wald ratio	1	1.14 (1.01, 1.30)	3.94 × 10−2

Note: The bold ones were those that survived multiple‐testing correction (Bonferroni P < .05).

Abbreviation: Chr, chromosome.