TABLE 3.
Gene‐alcohol interaction estimates for the risk of CRC nested in the UK Biobank
| Variables | Basic model | Multivariable model | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Alcohol (10 g/day) | 1.08 (1.05, 1.10) | 4.10 × 10−12 | 1.06 (1.04, 1.09) | 3.86 × 10−8 |
| rs3087967 | 1.08 (1.01, 1.15) | .022 | 1.08 (1.01, 1.16) | .018 |
| rs11213823 | 1.07 (1.00, 1.14) | .043 | 1.07 (1.00, 1.15) | .035 |
| rs3087967 × Alcohol (10 g/day) | 1.04 (1.01, 1.06) | .001 | 1.03 (1.00, 1.05) | .027 |
| rs11213823 × Alcohol (10 g/day) | 1.04 (1.02, 1.06) | .001 | 1.03 (1.00, 1.05) | .016 |
Note: Basic model: adjusted for age and sex; multivariable model: additionally adjusted for area deprivation index, red meat consumption, processed meat consumption, aspirin intake, BMI and smoking.