TABLE 4.
Dose‐response effect of alcohol drinking on the risk of CRC stratified by the genotype of rs3087967 in the UK Biobank
| Alcohol (10 g/day) | Basic model | Multivariable model | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| rs3087967 CC | 1.03 (0.97, 1.10) | .392 | 1.01 (0.95, 1.09) | .710 |
| rs3087967 CT | 1.07 (1.04, 1.11) | 6.99 × 10−6 | 1.07 (1.04, 1.11) | 1.54 × 10−5 |
| rs3087967 TT | 1.09 (1.06, 1.13) | 7.09 × 10−9 | 1.08 (1.05, 1.12) | 4.43 × 10−7 |
| rs11213823 CC | 1.03 (0.96, 1.09) | .401 | 1.01 (0.94, 1.08) | .822 |
| rs11213823 CT | 1.07 (1.04, 1.11) | 5.66 × 10−6 | 1.06 (1.03, 1.10) | 1.72 × 10−4 |
| rs11213823 TT | 1.09 (1.06, 1.12) | 5.88 × 10−8 | 1.07 (1.04, 1.11) | 1.58 × 10−5 |
Note: Basic model: adjusted for age and sex; multivariable model: additionally adjusted for area deprivation index, red meat consumption, processed meat consumption, aspirin intake, BMI and smoking.