TABLE 1.
Putative functions | |
miR-29a-3p | Collagen gene expression – apoptosis |
miR-29b-3p | Collagen gene expression |
miR-29c-3p | ECM-related genes expression |
miR-21-5p | EMT – collagen expression – SMAD7 |
miR-92a-3p | MMP-1 expression |
miR-26a-5p | EMT – collagen expression |
let-7d-5p | EMT |
The table shows candidate functions for each major overlapping miRNA in systemic sclerosis and idiopathic pulmonary fibrosis, and provides an overview of the specific functions in fibrogenesis regulated by a specific miRNA. ECM: extracellular matrix; SMAD7: small mother against decapentaplegic protein 7; MMP-1: matrix metalloproteinase 1; EMT: epithelial–mesenchymal transition.