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Correlation of sample size and date of publication regarding approved combinations (blue line and squares), TKIs (orange line and triangles) and single drugs except TKIs (green line and dots). The black line shows the correlation of sample size and date for all approved drugs and combinations. TKI trimmed (red line): shows data without the two first trials for erlotinib and gefitinib [18, 20]. TKI: tyrosine kinase inhibitor.
