TABLE 1.

Clinical trials investigating oligometastatic disease

Identifier	Title	Description	Allocation	Status
NCT03965468	Immunotherapy, chemotherapy, radiotherapy and surgery for synchronous oligo-metastatic NSCLC	Immunotherapy, chemotherapy plus stereotactic radiotherapy to synchronous oligo-metastases followed by definitive surgery or radiotherapy to primary NSCLC		Recruiting
NCT03827577	OMEGA, local ablative therapy in oligometastatic NSCLC	Resection of primary NSCLC plus local ablative therapy to all metastases versus standard-of-care chemotherapy	Randomised	Recruiting
NCT03275597	Phase Ib study of stereotactic body radiotherapy (SBRT) in oligometastatic non-small lung cancer (NSCLC) with dual immune checkpoint inhibition	SBRT followed by combined durvalumab and tremelimumab		Recruiting
NCT03119519	Local non-salvage radiotherapy for synchronous oligometastatic non-small-cell lung cancer	Chemotherapy plus local definitive radiotherapy to primary and oligo-metastases versus standard-of-care chemo-/targeted-therapy	Randomised	Recruiting
NCT02975609	Phase II trial of SBRT compared with conventional radiotherapy for oligometastatic non-small cell lung cancer	Chemotherapy plus SBRT versus chemotherapy plus conventional fractionated radiotherapy to primary and all metastatic sites	Randomised	Not yet recruiting
NCT02417662	Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer	Patients will be randomised to receive either standard chemotherapy treatment alone or standard treatment with conventional radiotherapy and SABR	Randomised	Recruiting
NCT02054819	Treating NSCLC minimal stage IV with curative intent	Platinum-based chemotherapy with concurrent radiation therapy to the primary tumour and identified mediastinal lymph nodal metastatic drainage. Local curative radiation will then target the oligometastatic tumour sites		Terminated (low accrual)
NCT01185639	Stereotactic body radiation therapy (SBRT) in metastatic non-small cell lung cancer	Chemotherapy followed by local ablative radiotherapy to all metastatic lesions		Completed

NSCLC: nonsmall cell lung cancer; SBRT: stereotactic body radiotherapy; SABR: stereotactic ablative radiotherapy.