TABLE 3.

Antipsychotics: experimental testing, drug and measured performance parameters.

References	Sample size	Experimental testing	Drug	Time of drug intake	Performance and physical parameters (primary/secondary)	Statistical outcome (data compared to placebo/all trials)
Adamson et al. (17)	N = 5	Visual stimulus test. Grip strength test. Lumbar pull. Chinnings (pull-ups).	Oxypertine 0 mg/5 mg/10 mg/20 mg/40 mg.	Each dose repeated twice 2 h before starting the tests.	Secondary: Reaction time. Grip strength. Lumbar pull. Chinning number.	Reaction time: →. Grip strength: ↓. Lumbar pull: ↓. Chinning number: →.
Kim et al. (39)	N = 30 HC = 15	Incremental cycling (start at 30 W with an increase of 10 W per minute) until exhaustion.	Clozapine: participants treated were divided into groups based on their antipsychotic medication status: those treated mainly with clozapine (i.e., in an amount greater than 50% of total CPZE) comprised the clozapine group, those treated mainly with other antipsychotics (i.e., in an amount greater than 50% of total CPZE) comprised the non-clozapine group.		Primary: Resting heart rate. Peak heart rate. Heart rate reserve. Secondary: VO2 peak. Oxygen pulse. Ventilation. Respiratory exchange ratio. RPE.	Resting heart rate: ↑. Peak heart rate: ↑. Heart rate reserve: ↓. VO2 peak: ↓. Oxygen pulse: →. Respiratory exchange ratio: →. RPE: → (compared to the non-clozapine group).
Perez-Cruzado et al. (40)	N = 62	Physical fitness test battery: – Passive knee extension test. – Calf muscle flexibility test. – Anterior hip flexibility test. – Functional shoulder rotation test. – Timed-stand test. – Partial sit-up test. – Seated push-up test. – Grip test. – Single leg stance (open and closed eyes). – Functional reach test. – 2-min step test.	Risperidone consumer. Olanzapine consumer.		Secondary: Physical fitness: Aerobic condition. Flexibility. Balance. Strength.	Risperidone: Flexibility: →. Balance: →. Strength: →. Aerobic condition: ↓ (compared to the non-risperidone-group). Olanzapine: Flexibility: →. Balance: ↓. Strength: ↓. Aerobic condition: ↓ (compared to the non-olanzapine-group).

N, total sample size; RPE, rating of perceived exertion; →, no changes; ↑, increase/longer time; ↓, decrease/shorter time; HC, healthy control.