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. 2020 May 27;29(156):190168. doi: 10.1183/16000617.0168-2019

FIGURE 4.

FIGURE 4

Interstitial remodelling patterns in pulmonary veno-occlusive disease (PVOD) eukaryotic translation initiation factor 2 α kinase 4 (EIF2AK4) mutation carriers and non-carriers. a) EIF2AK4 mutation carrier with patchy pulmonary capillary haemangiomatosis (PCH)-like foci (inset) (haematoxylin–eosin staining). b) EIF2AK4 mutation non-carrier with more diffuse PCH-like remodelling (inset) (haematoxylin–eosin staining). Scale bars=1000 µm. c) EIF2AK4 mutation carriers display a significantly higher degree of patchy PCH-like foci (p=0.014), whereas non-carriers show instead more diffuse PCH-like remodelling. EIF2AK4-C: PVOD EIF2AK4 mutation carriers; EIF2AK4-NC: PVOD EIF2AK4 non-carriers. *: p<0.05. Reproduced from [28] with permission.