TABLE 2.
List of Antidotes on the Formulary before and after the RCA.
| Formulary Antidotes Before | Formulary Antidotes After | Indication |
| Acetylcysteine injection | Acetylcysteine injection | Acetaminophen toxicity |
| NA | Andexanet alfa injection | Reversal of anticoagulation for patients treated with a direct factor Xa inhibitor (apixaban or rivaroxaban) |
| Atropine injection | Atropine injection | Organophosphate pesticide or nerve agent poisoning, carbamate toxicity |
| Calcium Chloride 10% prefilled syringe | Calcium Chloride 10% prefilled syringe | Fluoride, calcium channel blocking agent toxicity |
| NA | Calcium gluconate gel 2.5% | Hydrofluoric acid dermal burns |
| Calcium gluconate injection 10% | Calcium gluconate injection 10% | Fluoride, calcium channel blocking agent toxicity |
| Cyproheptadine tablet | Cyproheptadine tablet | Serotonin toxicity |
| Dantrolene sodium injection | Dantrolene sodium injection | Malignant hyperthermia |
| Deferoxamine mesylate injection | Deferoxamine mesylate injection | Iron poisoning |
| Digoxin immune fab injection | Digoxin immune fab injection | Cardiac glycosides toxicity or cardiac steroid toxicity |
| Dimercaprol injection (BAL in oil) injection | Dimercaprol injection (BAL in oil) injection | Heavy metal toxicity (arsenic, lead, mercury) |
| NA | Edetate calcium disodium/EDTA ampule | Lead poisoning |
| NA | Ethanol dehydrated alcohol injection | Methanol or ethylene glycol poisoning |
| Flumazenil injection | Flumazenil injection | Benzodiazepine toxicity |
| Fomepizole injection | Fomepizole injection | Methanol or ethylene glycol poisoning |
| Glucagon prefilled syringe | Glucagon prefilled syringe | β-blocker, calcium channel blocker toxicity |
| Hydroxocobalamin injection | Hydroxocobalamin injection | Cyanide poisoning |
| NA | Idarucizumab injection | Reversal of anticoagulant effects of dabigatran |
| L-carnitine vials | L-carnitine vials | Valproic acid toxicity |
| Leucovorin calcium vial | Leucovorin calcium vial | Methotrexate or methanol toxicity |
| Methylene blue injection | Methylene blue injection | Methemoglobinemia, ifosfamide induced encephalopathy |
| Naloxone injection | Naloxone injection | Opioid toxicity |
| Octreotide vial | Octreotide vial | Sulfonylurea-induced hypoglycemia |
| NA | Pentetate calcium trisodium injection (Calcium DTPA) | Internal contamination with plutonium, americium, or curium to increase the rates of elimination |
| Phentolamine mesylate injection | Phentolamine mesylate injection | Extravasation |
| Physostigmine injection | Physostigmine injection | Anticholinergic syndrome |
| Phytonadione injection | Phytonadione injection | Reversal of coumarin-induced coagulopathy |
| Phytonadione tablet | Phytonadione tablet | Reversal of coumarin-induced coagulopathy |
| Polyvalanet snake antivenom injection | Polyvalanet snake antivenom injection | Snake envenomation |
| Polyvalent scorpion antivenom injection | Polyvalent scorpion antivenom injection | Scorpion envenomation |
| Potassium iodide tablet | Potassium iodide tablet | Thyroid radioiodine protection |
| Pralidoxime chloride injection | Pralidoxime chloride injection | Organophosphorus poisoning |
| Protamine sulfate injection | Protamine sulfate injection | Reversal of coagulopathy induced by unfractionated or low-molecular-weight heparin |
| NA | Prussian blue capsule | Thallium or radiocesium toxicity |
| Pyridoxine tablet | Pyridoxine tablet | Isoniazid or hydrazine toxicity |
| Regular human insulin vial | Regular human insulin vial | Beta-blocker toxicity, calcium-channel blocker toxicity |
| Smoflipid 20% lipid injectable emulsion | Smoflipid 20% lipid injectable emulsion | Local anesthetic systemic toxicity |
| Sodium bicarbonate injection 8.4% injection | Sodium bicarbonate injection 8.4% injection | Tricyclic antidepressant toxicity, urine alkalization for salicylate toxicity, or cocaine toxicity |
| NA | Sodium Thiosulphate injection | Extravasation |
| NA | Succimer DMSA capsule | Heavy metal toxicity (arsenic, lead, mercury) |
| Sugammadex injection | Sugammadex injection | Reversal of neuromuscular blockade |
| Thiamine hydrochloride injection | Thiamine hydrochloride injection | Ethylene glycol toxicity, thiamine deficiency associated with chronic alcoholism |
| Unactivated prothrombin complex concentrates 4 factors II, VII, IX, X, with proteins S and C injection | Unactivated prothrombin complex concentrates 4 factors II, VII, IX, X, with proteins S and C injection | Reversal of anticoagulant bleeding |
| NA | uridine triacetate 10gram/packet oral granules | Fluorouracil or capecitabine overdose regardless of symptoms or early-onset toxicity |
NA: Not available on the formulary