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Forest plot of the a) sensitivity and b) specificity of different pulmonary function test screening algorithms for the presence of systemic sclerosis-associated interstitial lung disease [159, 213]. For the study by Bernstein [213], 95% CIs were calculated using reported measures of sensitivity, specificity, positive predictive value and negative predictive value. DLCO: diffusing capacity of the lung for carbon monoxide; FVC: forced vital capacity; TLC: total lung capacity.
