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Potential sites of action of phosphodiesterase (PDE) inhibitors and soluble guanylyl cyclase (sGC) activators in airways smooth muscle and inflammatory cells. AC: adenylyl cyclase; (c)AMP: (cyclic) adenosine monophosphate; (c)GMP: (cyclic) guanosine monophosphate; GC: guanylyl cyclase; NO: nitric oxide; PKG: protein kinase G.
