FIGURE 1.

Systems medicine-based approaches in interstitial lung diseases seek to analyse biological products (e.g. RNA, DNA, proteins, metabolites, microbiome, etc.) and, through massive data generation and integration with clinical features, help to identify biomarkers that can predict disease phenotypes. OTU: operational taxonomic unit; MUC5B: mucin 5B; ICAM-1: intracellular adhesion molecule-1; MMP-7: metalloproteinase-7; TOLLIP: Toll-interacting protein; TERT: telomerase reverse transcriptase.