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Platelet-derived growth factor receptors (PDGFRs) and ligand patterns. PDGFRs are transmembrane proteins. The extracellular domain consists of five immunoglobulin-like domains; binding occurs at domains 2 and 3. The intracellular domain is a tyrosine kinase. There are three dimeric forms of PDGFRs (-αα, -ββ and -αβ). Five different ligand isoforms are known to bind to PDGFRs (AA, AB, BB, CC and DD).
