TABLE 2.
Summary of drug targets and median inhibitory concentration (IC50)
| Drug target | IC50 nM | |
| Imatinib [39, 40] | PDGFR V-Abl C-Kit |
100 600 100 |
| Linifanib [41] | PDGFR-β KDR CSF-1R Flt-1/3 |
66 4 3 3/4 |
| Nintedanib [42, 43] | PDGFR-α/β VEGFR1/2/3 FGFR1/2/3 |
59/65 34/13/13 69/37/108 |
| PK10453 [44] | PDGFR-α/β | 10.1/35 |
| Sorafenib [43, 45] | PDGFR-β Raf-1 B-Raf VEGFR-2 |
57 6 22 90 |
| Sunitinib [46] | PDGFR-β VEGFR2 (Flk-1) |
2 80 |
| Pirfenidone | TGF-β PDGF-A and -B |
NA NA |
PDGFR: platelet-derived growth factor receptor; VEGFR: vascular endothelial growth factor receptor; FGFR: fibroblast growth factor receptor; TGF: transforming growth factor; NA: not available.