Table 2.

The role of ferroptosis in CVDs.

Disease	Factors	Mechanism	Role	Reference
MI	miR-23a-3p	Inhibit DMT1 expression	Inhibit ferroptosis and reduce myocardial injury	[47]
	BACH1	Adjust the threshold of iron ion induction	Inhibit ferroptosis	[48]
Reperfusion injury	C3G	Decreased Fe2+, downregulated TfR1 expression, upregulated Fth1 and GPX4 expression	Inhibit ferroptosis and reduce myocardial injury	[57]
	Res	Decreased Fe2+, downregulated TfR1 expression, upregulated Fth1 and GPX4 expression	Inhibit ferroptosis and reduce myocardial injury	[58]
	Lip-1	Reduce VDAC1 level and increase GPX4 level	Reduce I/R injury	[126]
	Eto	Induced Nrf2 nuclear translocation	Inhibit I/R-induced ferroptosis, improve fibrosis	[127]
AS	SIRT1	Reduce IL-1β and IL-18 levels	Inhibit ferroptosis and limit AS development	[64]
	PDSS2	Activate Nrf2, inhibit ROS release and reduce iron levels	Promote the proliferation of HCAECs and limit AS development	[65]
	miR-17-92	Targeting zinc lipoprotein A20 reduces Acsl4 expression and ROS accumulation	Inhibit ferroptosis	[66]
	CD98hc	Unknown	Promote VSMCs proliferation and prevent atherosclerotic thrombosis	[34]
Hypertension	Monocrotaline (MCT)	Activate the the HMGB1/TLR4/NLRP3 inflammatory pathway	Promote ferroptosis	[73]
	Celastrol	Increase HO-1 expression and decrease ROS production	Reduce inflammation and oxidative stress in VSMCs caused by hypertension	[74]
	CA	Regulate iron metabolism	Improve PAH	[76]
	Elabela	Regulate the IL-6/STAT3/GPX4 signalling pathway	Inhibit AngII-induced ferroptosis in poor myocardial remodelling, fibrosis and cardiac dysfunction	[79]
Myocardial hypertrophy	DHA	Increase IRF3-SLC7A11, decrease ALOX12 and iron levels	Inhibit ferroptosis	[128]
	miR-351	Regulate the JNK/p53 signalling pathway	Inhibit ferroptosis and improve fibrosis	[84]
	LncRNA AAB	Sponge miR-30b-5p, induced imbalance of MMP9/TIMP1 and enhanced TfR-1	Promote ferroptosis	[86]
HF	CD147	Activate TRAF2-TAK1 signalling pathway	Promote cardiac remodelling and dysfunction	[91]
	TLR4 and NOX4	Unknown	Inhibit cardiac autophagy and ferroptosis in HF rats	[129]
DCM	TRIM46	Promote GPX4 ubiquitination	Resist cell damage caused by high glucose	[37]
	PA	Reduce HSF1 and GPX4	Promote ferroptosis and enhance endoplasmic reticulum stress	[39]
DIC	EMPA	Participate in NLRP3- and MYD88-related pathways	Inhibit ferroptosis, fibrosis, apoptosis and inflammation	[99]
	AsIV	Activate Nrf2 signalling pathway and increase GPX4 expression	Inhibit ferroptosis and improve fibrosis	[100]
Sepsis	LPS	Activate NCOA4 and SFXN1, increase free iron	Cause mitochondrial damage and promote ferroptosis	[108]
	Dexmedetomidine	Reduce HO-1 expression, increase GPX4 expression	Reduce sepsis-induced myocardial cell damage	[107]
Stroke	NCOA4	USP14 upregulates NCOA4 through deubiquitination	Silencing NCOA4 can eliminate the ferritinophagy induced by I/R injury	[102]
	CDKN1A	C9orf106/C9orf139-miR-22-3p-CDKN1A axes	Regulate ferroptosis during IS progression	[104]
	JUN	GAS5-miR-139-5p/miR-429-JUN axes
	HIF-1α	Inhibits ACSL4 expression in early IS	Against ferroptosis	[105]