Table 1.
KSHV antigens that might become the basis for effective KSHV vaccines.
Common name | Gene | Function | Reference | |
---|---|---|---|---|
Structural proteins | gB | ORF8 | Glycoprotein, cell fusion | 125 |
gH | ORF22 | Glycoprotein, binds ephrin receptors | 75 | |
gL | ORF47 | Glycoprotein, binds ephrin receptors | 75 | |
K8.1 | ORFK8.1 | Glycoprotein, binds heparan sulfate | 126 | |
KSHV complement-binding protein (KCP) | ORF4 | Glycoprotein, binds heparan sulfate and complement | 127 | |
gM | ORF39 | Glycoprotein, cell fusion | 77 | |
gN | ORF53 | Glycoprotein, cell fusion | 77 | |
ORF27 | ORF27 | Glycoprotein | 128 | |
ORF28 | ORF28 | Glycoprotein | 129 | |
ORF68 | ORF68 | Glycoprotein | 130 | |
Non-structural proteins | Latency-associated nuclear antigen 1 (LANA1) | ORF73 | Latent genome maintenance | 131 |
K1 | ORFK1 | Signaling glycoprotein | 132 | |
Viral Interleukin 6 (vlL6) | vlL6 | Homolog to human IL6 | 133 | |
Viral G protein-coupled receptor (vGPCR) | ORF74 | Signaling GPCR | 134 |