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. 2022 Sep 6;13:945409. doi: 10.3389/fimmu.2022.945409

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Copyright © 2022 Antoni, Pylaeva, Budeus, Jablonska, Klein-Hitpaß, Dudda and Flohé

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of inflammation, organ damage, and weight loss during sublethal sepsis. WT mice underwent sham or CLP surgery. (A) Concentration of creatine phosphokinase (CPK) as marker for muscle cell degradation, blood urea nitrogen (BUN) as marker for kidney damage, and IL-6 as marker for inflammation in the serum 24 h after surgery (each n = 10–15 mice per group). (B) Time course of the body weight after surgery. Data were normalized to the individual body weight before surgery (set as 100%). Data show median and interquartile range of n = 12 mice per group per time point. Significant differences between sham and CLP mice were tested using Mann–Whitney U-test. **p ≤ 0.01; ***p ≤ 0.001.