TABLE 2.
Prognosis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) with mechanical ventilation: summary of studies published after 2008
| First author [ref.], country (timeframe) | N | Patients | Methods | Hospital survival | Overall survival |
|
Yokoyama [44], Japan
(1998–2004) |
11 | MV for AE-IPF | NIV (IMV) CPAP 10 cmH2O, PS/PEEP 5/10 cmH2O |
45% (5/11) 3 month |
45% 3 month |
|
Mollica [46], Italy
(2000–2007) |
34 | MV for ARF in ICU | IMV or NIV V T 7.5 mL·kg−1 or PS/PEEP 18/7 cmH2O |
15% (5/34) | 3% 6 month |
|
Güngör [47], Turkey
(2000–2007) |
96 | MV for ARF in ICU | IMV or NIV V T 6–8 mL·kg−1, PEEP 5–7 cm H2O |
36% (35/96) | – |
|
Fernández-Pérez [45],
USA (2002–2006) |
30 | MV for ARF in ICU | IMV V T 7–8 mL·kg−1 |
40% (12/30) | – |
|
Gaudry [48], France
(2002–2009) |
22 | MV for ARF in ICU | IMV V T 5.9 mL·kg−1, PEEP 7.1 cm H2O |
23% (5/22) ICU discharge |
– |
|
Vianello [49], Italy
(2005–2013) |
18 | MV for ARF in ICU | NIV (IMV) V T 6–8 mL·kg−1, PEEP 6.4 cm H2O |
14% 90 days |
– |
| Total | 193 | 33% (63/193) | 13% |
MV: mechanical ventilation; NIV: noninvasive ventilation; IMV: invasive mechanical ventilation; CPAP: continuous positive pressure ventilation; PS: pressure support; PEEP: positive end-expiratory pressure; ARF: acute respiratory failure; ICU: intensive care unit; VT: tidal volume.