Table 2.

Predictive factors for overall survival

Factors	HR (95% CI)	P-value
Age	1.1 (0.9-1.3)	0.3
Gender (Female VS Male)	1 (0.7-1.5)	0.9
Higher number of metastases at first GK	1.1 (1.0-1.1)	0.001
Lowest GK dose	1.0 (0.9-1.1)	0.9
Primary diagnosis   Lung VS Melanoma   Renal VS Melanoma	1.2 (0.5-3.1) 1.9 (0.7-5.5)	0.6 0.2
Upfront immunotherapy	0.2 (0.1-0.4)	<0.0001

CI: confidence interval; GK: Gamma Knife; HR: hazard ratio