Figure 1.

A) Multivariate linear model of short-term percentage change in the overall severity of pain (ΔPFPS-R) was constructed with predictors significant on univariate analysis (model F-test, p = 0.006): BED, sex, and age. Histograms shows pain outcome and BED across individual patients (pain outcome outliers treated with winsorization). Fitted line (solid) was adjusted to isolate the effect of BED (predictor t-test, *p = 0.02, coefficient/slope = 0.09). Dotted lines indicate 95% confidence bounds. B) Distribution of BEDs in subjects in whom long-term data was available, divided into subsets based on post-radiosurgery development of facial numbness. The incidence of numbness was increased in patients treated with BEDs in the highest quartile (*p = 0.01). Patients reporting a 100% improvement in overall pain severity indicated with horizontal dotted lines. Vertical lines indicate 25th and 75th percentiles of BED.