Metabolomics
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Few relevant studies
Small sample sizes
Lack of strict control of confounding variables
Sensitive to complications
Lack of comparability due to different biofluids and platforms
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Standardised technologies and software as gold standards for future studies
Prospective studies strictly adjusting for confounding variables
To explore functional annotation of unknown metabolites and microbiota in various body fluids or cavities
To focus on microbial and metabolic signatures specific to OSA versus those common to other metabolic diseases
To elucidate casual relationships between metabolomics and the microbiome
More multi-omics studies using advanced approaches
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