TABLE 1.
34 studies on mixed-interstitial lung disease (IlD) and idiopathic pulmonary fibrosis (IPF) included in the systematic review
| First author [ref.] | Year | Country | Patients n | Patient population | Design |
| Mixed-ILD | |||||
| Churg [13] | 2007 | Canada | 12 | 9 patients with UIP, 2 with NSIP, 1 chronic HP undergoing lung biopsy for unknown cause of ARF | Retrospective |
| Fernandez-Perez [14] | 2008 | USA | 94 | ILD patients admitted to ICU requiring IMV for >24 h | Retrospective |
| Fumeaux [15] | 2001 | Switzerland | 14 | Pulmonary fibrosis patients admitted to ICU for IMV | Retrospective |
| Gaudry [16] | 2014 | France | 27 | IPF or fibrosing idiopathic NSIP who required IMV | Retrospective |
| Goncalves [17] | 2016 | Portugal | 37 | ILD ICU admissions | Retrospective |
| Gungor [18] | 2013 | Turkey | 120 | ILD ICU admissions | Retrospective |
| Huie [12] | 2010 | USA | 27 | Patients with fibrotic lung disease with acute respiratory decline | Retrospective (n=17)/ perspective (n=10) |
| Martinez [19] | 2015 | Australia | 36 | Patients admitted to the ICU with respiratory insufficiency secondary to IIP | Retrospective |
| Molina-Molina [20] | 2003 | Spain | 20 | ILD ICU admissions | Retrospective |
| Olson [21] | 2008 | USA | 4 | Fibrotic HP undergoing AE | Retrospective |
| Osman [22] | 2017 | Egypt | 91 | ILD RICU admissions | Perspective |
| Park [23] | 2007 | South Korea | 10 | Biopsy proven non-IPF ILD patients | Retrospective |
| Tachikawa [24] | 2012 | Japan | 62 | AE of CTD-ILD and IIP | Retrospective |
| Tomii [25] | 2010 | Japan | 33 | AE-interstitial pneumonia | Retrospective |
| Vial-Dupuy [26] | 2013 | France | 72 | ILD patients admitted to ICU due to ARF | Retrospective |
| Yokoyama [27] | 2012 | Japan | 38 | Rapidly progressing interstitial pneumonia treated with early NIMV | Retrospective |
| Zafrani [28] | 2014 | France | 83 | ILD-associated ARF | Retrospective |
| IPF | |||||
| Akira [29] | 1997 | Japan | 17 | Accelerated deterioration of IPF | Retrospective |
| Al-Hameed [30] | 2004 | Canada | 25 | AE-IPF ICU admissions | Retrospective |
| Ambrosini [31] | 2003 | Italy | 5 | AE-IPF ICU admissions | Retrospective |
| Blivet [32] | 2001 | France | 15 | IPF admitted for respiratory failure | Retrospective |
| Kim [33] | 2006 | Korea | 11 | Biopsy-proven AE-IPF | Retrospective |
| Kondoh [34] | 1993 | Japan | 3 | AE-IPF | Retrospective |
| Mollica [35] | 2010 | Italy | 34 | IPF patients undergoing IMV | Retrospective |
| Nava [36] | 1999 | Italy | 7 | End-stage IPF patients undergoing IMV | Retrospective |
| Oda [37] | 2016 | Japan | 209 | IPF with ARF requiring ventilation and high-dose steroids | Retrospective |
| Papiris [38] | 2015 | Greece | 17 | AE-IPF | Retrospective |
| Parambil [39] | 2005 | USA | 7 | AE-IPF ICU admissions | Retrospective |
| Rangappa [3] | 2009 | Australia | 24 | IPF patients admitted to the ICU | Retrospective |
| Saydain [40] | 2002 | USA | 38 | IPF patients admitted to the ICU | Retrospective |
| Song [41] | 2011 | South Korea | 90 | AE-IPF | Retrospective |
| Stern [42] | 2001 | France | 23 | IPF patients undergoing IMV | Retrospective |
| Vianello [43] | 2014 | Italy | 18 | IPF patients receiving NIMV for ARF | Retrospective |
| Yokoyama [44] | 2010 | France | 83 | ILD-associated ARF | Retrospective |
UIP: usual interstitial pneumonia; NSIP: nonspecific interstitial pneumonia; HP: hypersensitivity pneumonitis; ARF: acute respiratory failure; ICU: intensive care unit; IMV: invasive mechanical ventilation; IIP: idiopathic interstitial pneumonia; AE: acute exacerbation; RICU: respiratory ICU; CTD: connective tissue disease; NIMV: noninvasive mechanical ventilation.