TABLE 2.
Intensive care unit (ICU), in-hospital and follow-up mortality in patients with mixed-interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF)
| First author [ref]. | Inclusion years month/year | Total + | Included § | IPF | Overall deaths | ICU mortality % | In-hospital mortality % | Overall in-hospital mortality % | Follow-up mortality % |
| Mixed-ILD | |||||||||
| Churg [13] | Not provided | 12 | 12 | 9 | 2 | 13 | 13 | 36 (11 months) | |
| Fernandez-Perez [14] | 02/2002–07/2006 | 94 | 94 | 30 | 50 | 53 | 53 | 59 (1 year) | |
| Fumeaux [15]# | 12/1996–03/2001 | 14 | 14 | 11 | 14 | 100 | 100 | 100 | |
| Gaudry [16] | 01/2002–04/2009 | 27 | 27 | 22 | 23 | 77 | 85 | 85 | 96 (1 year) |
| Goncalves [17] | 01/2004–05/2015 | 37 | 37 | 5 | 23 | 62 | 62 | 81 (1 month) | |
| Gungor [18] | 01/2008–12/2010 | 120 | 120 | 96 | 72 | 60 | 60 | ||
| Huie [12] | 06/2006–04/2009 | 27 | 27 | 13 | 17 | 63 | 63 | 74 (2 months), 78 (6 months), 85 (1 year) | |
| Martinez [19]# | 12/2007–12/2013 | 36 | 36 | 25 | 25 | 55 | 69 | 69 | |
| Molina- Molina [20] | 01/1986–06/2002 | 20 | 20 | 14 | 20 | 95 | 100 | 100 | |
| Olson [21] | 01/2005–01/2007 | 4 | 4 | 0 | 4 | 100 | 100 | ||
| Osman [22] | 01/2013–07/2015 | 91 | 91 | 68 | 9 | 10 | 10 | ||
| Park [23] | 1993–04/2006 | 10 | 10 | 0 | 6 | 60 | 60 | 60 (6 months) | |
| Tachikawa [24]¶ | 1/2003–12/2009 | 62 | NI | NI | 90 (3 months) | ||||
| Tomii [25]¶ | 10/2001–09/2006 | 33 | NI | NI | 46 (2 months) | ||||
| Vial-Dupuy [26] | 7/1993–12/2009 | 72 | 72 | 16 | 33 | 46 | 46 | ||
| Yokoyama [27] | 01/2005–12/2010 | 38 | 38 | 16 | 21 | 54 | 54 | ||
| Zafrani [28] | 01/2002–03/2013 | 83 | 83 | 9 | 34 | 41 | 41 | 54 (1 years) | |
| Total | 780 | 685 | 334 | 353 | |||||
| IPF | |||||||||
| Akira [29]¶ | Not provided | 17 | NI | NI | 48 (3 months) | ||||
| Al-Hameed [30] | 09/1988–12/2001 | 25 | 25 | 25 | 24 | 84 | 96 | 96 | 100 (1 year) |
| Ambrosini [31] | 05/2001–06/2002 | 5 | 5 | 5 | 4 | 80 | 80 | 80 (1.5 years) | |
| Blivet [32] | 01/1989–06/1998 | 15 | 15 | 15 | 13 | 73 | 86 | 86 | |
| Kim [33] | 01/1990–09/2003 | 11 | 11 | 11 | 7 | 70 | 63 | 63 | 82 (3 months) |
| Kondoh [34] | Not provided | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 33 (6 months) |
| Mollica [35] | 01/2000–01/2007 | 34 | 34 | 34 | 29 | 85 | 85 | 97 (6 months) | |
| Nava [36] | Not provided | 7 | 7 | 7 | 6 | 85 | 85 | ||
| Oda [37] | 04/2010–03/2013 | 209 | 209 | 209 | 138 | 66 | 66 | ||
| Papiris [38] | 2007–06/2013 | 17 | 17 | 17 | 11 | 65 | 65 | ||
| Parambil [39] | 01/1996–12/2002 | 7 | 7 | 7 | 6 | 86 | 86 | 86 | |
| Rangappa [3] | 01/1996–12/2006 | 24 | 24 | 24 | 22 | 67 | 92 | 92 | |
| Saydain [40] | 01/1995–07/2000 | 38 | 38 | 38 | 23 | 45 | 61 | 61 | |
| Song [41] | 1990–2009 | 90 | 90 | 90 | 45 | 50 | 50 | ||
| Stern [42] | 09/1990–10/1999 | 23 | 23 | 23 | 22 | 96 | 96 | ||
| Vianello [43] | 01/2005–04/2013 | 18 | 18 | 18 | 10 | 55 | 55 | 86 (3 months), 100 (1 year) | |
| Yokoyama [44]¶ | 04/1998–06/2004 | 11 | NI | NI | 55 (3 months), 70 (6 months) | ||||
| Total | 554 | 526 | 526 | 360 |
Data are presented as n, unless otherwise stated. NI: not included in the overall mortality analysis. #: patients with radiological diagnosis of usual interstitial pneumonia who were not labelled as IPF in the original study but were considered IPF for our analysis; ¶: these studies provided information on follow-up mortality only; +: all the patients of 17 studies included in the systematic review; §: number of patients included in the ICU and in-hospital mortality analysis, [24, 25, 29, 44] were excluded.