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The complexity of obstructive sleep apnoea (OSA) for consideration in a personalised medicine approach. PSG: polysomnography; GWA: genome-wide association; EDS: excessive daytime sleepiness; PALM: Pcrit (passive critical closing pressure), arousal threshold, loop gain and muscle responsiveness; CCC: complete concentric palatal collapse; IL: interleukin; HTN: systemic hypertension. Reproduced and modified from [18] with permission.
