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The role of interleukin (IL)-5 in eosinophil biology. T helper type 2 (Th2) lymphocytes, group 2 innate lymphoid cells (ILC2), and mast cells release IL-5 in response to a variety of triggers, including inhaled allergens, respiratory viruses, and airborne pollutants. IL-5 promotes eosinophil maturation, migration out of the bone marrow, and recruitment to peripheral sites. IgE: immunoglobulin E; TSLP: thymic stromal lymphopoietin. Reproduced from Pelaia et al. [21].
