TABLE 1.

Outcomes of pulmonary endarterectomy in patients with proximal (type 1 and type 2) or distal (type 3) chronic thromboembolic pulmonary hypertension (CTEPH) disease distribution

	Proximal	Distal
Subjects n	221	110
mPAP mmHg
Pre-operative	44±10	46±11
At discharge	22±7	24±6
3-month follow-up	24±9	25±7
12-month follow-up	23±7	24±8
p-value#	<0.001	<0.001
PVR dyn·s·cm–5
Pre-operative	876±392	926±337
At discharge	251±146	295±161
3-month follow-up	270±175	300±139
12-month follow-up	243±115	300±224
p-value#	<0.001	<0.001
PaO2 mmHg
Pre-operative	65±12	66±11
3-month follow-up	82±13	80±11
12-month follow-up	80±11	80±11
p-value#	<0.001	<0.001
Modified Bruce exercise test m
Pre-operative	51 (0−143)	52 (0−102)
3-month follow-up	495 (182−658)	435 (143−586)
12-month follow-up	520 (261−709)	474 (225−620)
p-value#	<0.001	<0.001
6-min walking distance m
Pre-operative	277±118	289±112
3-month follow-up	391±118	398±107
12-month follow-up	389±118	396±112
p-value#	<0.001	<0.001

Data are presented as mean±sd or median (interquartile range), unless otherwise stated. mPAP: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; P_aO2: arterial oxygen tension. Tests of interaction are as follows. mPAP: p=0.975; PVR: p=0.777; P_aO2: p=0.317; modified Bruce exercise test: p=0.205; 6-min walking distance: p=0.962. ^#: versus pre-operative. Reproduced and modified from [24] with permission from the publisher.