Figure 5. V1 optogenetic suppression disrupts distance estimation task performance.

(A) Schematic of experimental setup for optogenetic experiments; bilateral illumination of either binocular or monocular zone V1 in either binocular or monocular animals during the decision period on one-third of trials. All plots within a column correspond to the schematized condition. (B) Performance curves for laser-off (black) and laser-on (cyan) conditions in mice expressing ChR2 in PV+ inhibitory interneurons (ChR2+, top row) or PV-Cre only mice (ChR2-, bottom row). Thin lines are individual animal data. (C) Change in the mean and standard deviation of landing positions, averaged across mice. Small circles are individual animal data. (D) Change in the mean head angle for up-down (pitch) and side-to-side (yaw) head position. (E) Same as (D) but change in standard deviation of pitch and yaw.

Figure 5—figure supplement 1. V1 optogenetic suppression task performance.

(A) Rates of failure (left column), success (middle column), and abort trials (right column) for binocular vision with optogenetic suppression of binocular zone V1. Top row shows data from animals expressing ChR2 in PV+ interneurons, and bottom row is animals lacking ChR2. Blue lines indicate laser on trials, and black lines indicate laser-off trials. (B) Same as (A) but for monocular vision with binocular zone V1 suppression. (C) Same as (B) but for monocular vision with monocular zone V1 suppression. Note that data in (C) were collected with different platform geometry and gap distances (see ‘Materials and methods’ for details).