. 2022 Aug 26;11:e76207. doi: 10.7554/eLife.76207

Table 1. Estimated MRONJ case numbers in the US based on MRONJ incidence for the major underlying diseases^*.

Underlying diseases	New cases in the US (Year)	MRONJ incidence	Estimated MRONJ cases (Year)^*
Multiple myeloma	34,920^†	5.16% (Rugani et al., 2016)	1,802
Breast cancer	330,840^‡	2.09% (Rugani et al., 2016)	6,915
Prostate cancer	248,530^†	3.80% (Rugani et al., 2016)	9,444
Osteoporosis/Low bone mass	53,500,000^§	0.01% (Khan et al., 2017)	5,350
Estimated annual incidents of MRONJ			23,511

MRONJ: Medication-related osteonecrosis in the jawbone.

Based on an assumption that all these patients were treated by antiresorptive medications.

^†

American Cancer Society. Cancer Facts & Figures 2021. Atlanta, Ga: American Cancer Society; 2021.

^‡

Invasive breast cancer and ductal carcinoma: American Cancer Society. How Common Is Breast Cancer? Jan. 2020. Available at: https://www.cancer.org/cancer/breast-cancer/about/how-common-is-breast-cancer.html.

^§

Table 1. Estimated MRONJ case numbers in the US based on MRONJ incidence for the major underlying diseases*.