Table 2. Best fit model parameters and corresponding costs with different number of slots.
| Parameter | Description | Mslots = 1 | Mslots = 2 | Mslots = 3 | Mslots = 4 | Mslots = 5 | Mslots = 6 |
|---|---|---|---|---|---|---|---|
| α (µM–2s–1) | Ca2+ association rate constant | 0.03712 | 34.99 | 24.70 | 25.08 | 24.51 | 24.11 |
| γ (µM–1s–1) | PI(4,5)P2 association rate constant | 1.425·105 | 572.6 | 124.7 | 121.3 | 124.31 | 126.6 |
| [PI(4,5)P2] (µM) | Effective PI(4,5)P2 concentration for syt | 0.009658 | 0.2523 | 1.109 | 0.4528 | 0.3048 | 0.2320 |
|
f (Esyt (kbT)) |
Factor on the release rate for each Ca2+/PI(4,5)P2 dual bound C2B domain (resulting from a fusion barrier reduction of Esyt) | 4.259·106 (15.3) | 1298 (7.17) |
128.2 (4.85) |
152.1 (5.02) |
159.6 (5.07) | 163.5 (5.10) |
| d (ms) | Added delay | 0.3211 | 0.3761 | 0.3803 | 0.3866 | 0.3876 | 0.3881 |
| Costs | Quantification of goodness of fit | 581.9 | –92.50 | –139.4 | –130.3 | –127.7 | –126.5 |