Table 4.
BMI and risk for GC subtype according to histological classification in the ACC 1
| BMI (kg/m2) | |||||
|---|---|---|---|---|---|
|
| |||||
| < 18.5 | 18.5–22.9 | 23.0–24.9 | 25.0–27.4 | ≥ 27.5 | |
|
| |||||
| Intestinal type GC | |||||
| HR (95% CI)2 | 1.14 (1.01–1.28) | 1.07 (0.99–1.15) | 1 | 0.96 (0.87–1.06) | 1.11 (0.98–1.25) |
| Cases, N | 400 | 2,455 | 1,065 | 664 | 360 |
| Diffuse type GC | |||||
| HR (95% CI)2 | 0.99 (0.63–1.55) | 1.22 (0.95–1.57) | 1 | 1.17 (0.85–1.61) | 1.27 (0.85–1.89) |
| Cases, N | 26 | 224 | 83 | 67 | 35 |
| Female | |||||
| Intestinal type GC | |||||
| HR (95% CI)3 | 1.51 (1.24–1.83) | 1.10 (0.96–1.26) | 1 | 1.00 (0.84–1.19) | 1.07 (0.88–1.30) |
| Cases, N | 167 | 718 | 304 | 226 | 148 |
| Diffuse type GC | |||||
| HR (95% CI)3 | 0.96 (0.53–1.74) | 1.06 (0.75–1.49) | 1 | 0.97 (0.62–1.52) | 1.14 (0.69–1.89) |
| Cases, N | 15 | 111 | 48 | 33 | 22 |
| Male | |||||
| Intestinal type GC | |||||
| HR (95% CI)3 | 1.02 (0.88–1.19) | 1.06 (0.97–1.16) | 1 | 0.94 (0.83–1.05) | 1.13 (0.97–1.32) |
| Cases, N | 233 | 1,737 | 761 | 438 | 212 |
| Diffuse type GC | |||||
| HR (95% CI)3 | 1.09 (0.55–2.18) | 1.47 (1.00–2.15) | 1 | 1.50 (0.93–2.41) | 1.49 (0.79–2.83) |
| Cases, N | 11 | 113 | 35 | 34 | 13 |
Abbreviation: BMI, Body mass index; GC, Gastric cancer; ACC, Asia Cohort Consortium
1.
Analyzed excluding cases diagnosed within 2-year from cohort enrollment
2.
Adjusted for age at cohort enrollment, sex, country, cigarette smoking status and alcohol drinking status
3.
Adjusted for age at cohort enrollment, country, cigarette smoking status and alcohol drinking status