Table 3.
All-cause mortality in IBD patients with CRC by different colonoscopy intervals adjusted for lead time bias
| Adjusted Model | ||
|---|---|---|
| HR [95% CI] | P-value | |
| Colonoscopy Interval (years) | ||
| > 5 pre-CRC diagnosis | Ref | |
| ≤1yr pre-CRC diagnosis | 0.56 (0.36–0.88) | 0.01 |
| >1–3 pre-CRC diagnosis | 0.81 (0.59–1.12) | 0.22 |
| >3–5 pre-CRC diagnosis | 0.82 (0.43–1.54) | 0.53 |
| Age at CRC index (years) | 1.03 (1.01–1.04) | <.0001 |
| Gender | ||
| Male | Ref | |
| Female | 1.14 (0.57–2.27) | 0.71 |
| Race | ||
| Caucasian | Ref | |
| African American | 1.24 (0.73–2.11) | 0.43 |
| Hispanics | 0.81 (0.41–1.63) | 0.55 |
| Asian/Native American/Others | 0.49 (0.14–1.68) | 0.25 |
| IBD type | ||
| Ulcerative Colitis | Ref | |
| Crohn’s Disease | 1.11 (0.88–1.39) | 0.38 |
| IBD unclassified | 0.70 (0.33–1.45) | 0.33 |
| IBD extension | ||
| No | Ref | |
| Yes | 1.22 (0.91–1.65) | 0.19 |
| IBD duration (years) | 1.00 (1.00–1.01) | 0.38 |
| CRC stage | ||
| 0–2 | Ref | |
| 3–4 | 2.99 (2.26–3.95) | <.0001 |
| Unknown | 0.91 (0.67–1.27) | 0.57 |
| Colonoscopy surveillance indication | ||
| No | Ref | |
| Yes | 0.87 (0.66–1.15) | 0.33 |
| Primary Sclerosing Cholangitis | ||
| No | Ref | |
| Yes | 1.10 (0.53–2.27) | 0.80 |
| Tobacco Use | ||
| No | Ref | |
| Yes | 1.00 (0.79–1.26) | 0.99 |
| Alcohol abuse | ||
| No | Ref | |
| Yes | 1.07 (0.77–1.48) | 0.70 |
| Comorbidity Score | ||
| 0 | Ref | |
| 1 | 1.28 (0.97–1.69) | 0.08 |
| ≥2 | 1.22 (0.82–1.84) | 0.33 |
| IBD facility volume | 1.0 (1.0–1.0) | 0.20 |
IBD (Inflammatory Bowel Disease), CRC (Colorectal Cancer)