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. 2022 Jun 16;6(9):1292–1309. doi: 10.1038/s41562-022-01359-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Results of GWAS in N = 606,825 participants with 23andMe. The GWAS phenotype is the participants’ responses of Yes (N = 555,660) versus No (N = 51,165) to the question ‘Can you clap in time with a musical beat?’. The GWAS was performed with logistic regression, controlling for age, sex, the top five principal components for ancestry and genotype platform. The x axis shows chromosomal positions, and the y axis shows −log₁₀ P values of the association between the alleles and the phenotype. Sixty-nine loci (70 sentinel SNPs, with one locus containing two independent sentinel SNPs) surpassed the threshold for genome-wide significance of P < 5 × 10⁻⁸ (dashed horizontal line). For illustration purposes, all SNPs with P < 5 × 10⁻⁷ are shown, and SNPs between P = 5 × 10⁻⁷ and 1 were downsampled to an evenly distributed draw of 30,880 SNPs; gene symbols for sentinel SNPs are notated when FUMA provided a gene mapped to the nearest sentinel SNP.