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. 2022 Jun 16;6(9):1292–1309. doi: 10.1038/s41562-022-01359-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Genes associated with beat synchronization are enriched for expression in brain tissue. The results of MAGMA gene-property analysis are based on gene expression levels from GTEx v.8, in 54 tissues, conditioned on average expression across tissues. Associations with beat synchronization were significantly enriched in brain-expressed genes (−log₁₀ P values are on the y axis, with tissue types on the x axis). The dashed line shows the P value threshold for significant enrichment after Bonferroni correction. b, Partitioned heritability shows enrichment in brain-specific regulatory regions of the genome. Partitioned heritability analysis was performed with LDSC–SEG. Tissue-specific regulatory elements are marked by histone 3 acetylation or DNase hypersensitivity (for open chromatin) and H3K4me1 (for enhancers). Regulatory regions in adult brain tissues are shown in yellow, regulatory elements in cell cultures are shown in teal and regulatory elements in fetal brain tissue are shown in dark purple. The graph shows −log₁₀ P values on the y axis, with tissue and marker types on the x axis. The dashed line shows the P value threshold for significant enrichment after Bonferroni correction for the number of gene sets tested.

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