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. 2022 Jun 25;31(4-5):413–430. doi: 10.1007/s11248-022-00314-w

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The first triple transgenic line of Tg1 x Tg2 x Tg3-TETX was generated to demonstrate that the action of tetanus toxin (TeTX) blocks neurotransmission in specific neurons in the hippocampus when Dox is not administered. Administration of Dox can reversibly release this blockade of neurotransmission. The second crossbred of Tg1 x Tg2 x Tg3-GFP was to visualize neurons with GFP in the dentate gyrus (DG) of the hippocampus and the pyramidal neurons of CA3, and the expression of GFP disappeared by administration of Dox