Table 1.D.

Models for risk factors for first late PTS (i.e., PTE) and PTS Recurrence. The first model is a Cox Proportional Hazards (CPH) model predicting the first late PTS (i.e., PTE). As a sensitivity analysis, we developed a competing risks regression using the same inputs as our first model and modeling the competing hazard of death. Both models predict the occurrence of the first late PTS. Our third model predicts PTS recurrence, or the second PTS. In this last model, we include the occurrence of a first late PTS as a time-varying covariate, as the first late PTS occurs during follow up and, by definition, prior to PTS recurrence. *The CRR model reports the subdistribution hazard.

Cumulative Incidence	Model Type	Variable	Hazard Ratio*	95% CI		P-value
First late PTS (PTE)	CPH	DHC	4.1	2.2	6.1	<0.001
		CNS Infection	1.7	1.2	2.3	0.04
		Age (decade)	0.7	0.6	0.9	<0.001
First late PTS (PTE)	CRR	DHC	4.4	3.7	4.9	<0.001
		CNS Infection	1.7	1.2	2.2	0.03
		Age (decade)	0.7	0.6	0.9	<0.001
PTS Recurrence	CPH with time-varying coefficient	Shunt Dependence	0.6	0.3	1.0	0.04
		Sex (male)	2.7	1.4	5.3	<0.01