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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Periodontol. 2022 Apr 11:10.1002/JPER.21-0668. doi: 10.1002/JPER.21-0668

Figure 1: Ifi204 is protective against experimental periodontitis induced bone loss.

Figure 1:

Murine periodontal tissues were evaluated under health and 9-days after ligature placement. A) The expression of Ifi204 and Aim2 was identified in multiple cells of periodontal tissues of WT mice (magnification 20x). B) Alveolar bone levels were measured by micro-CT analysis in Ifi204−/− mice, from the cementoenamel junction to the alveolar bone crest (CEJ-ABC). Ifi204−/− mice showed increased bone loss compared to (healthy) WT. C) Superimposition of the scanned maxilla depicting the bone levels in health and disease (image represents mean loss/group). Healthy bone levels were similar in WT and Ifi204−/− mice (grey color); tan colors illustrate the bone level differences in periodontitis when comparing WT (light) and Ifi204−/−(dark). D) No significant differences in alveolar bone levels identified between WT and Aim2−/− mice. Error bars, s.e. (n=12, dependent on the predicted ligature loss).