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. 2022 Jul 24;179(20):4829–4843. doi: 10.1111/bph.15915

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© 2022 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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A genetic algorithm (GA) optimized a voltage clamp (VC) protocol to isolate individual current contributions in an in silico induced pluripotent stem cell‐derived cardiomyocyte (iPSC‐CM) model. (a) The GA was used to develop individual VC protocols for seven of the most predominant ionic currents in cardiac cells. (b) These seven protocols were systematically shortened and joined together by a −80‐mV holding step to produce an optimized VC protocol that isolates each of the seven currents.