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. 2022 Jul 24;179(20):4829–4843. doi: 10.1111/bph.15915

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© 2022 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Drug treatment resulted in action potential (AP) morphology changes consistent with the effects caused by drug block of the expected currents. Four cells with dynamically clamped I_K1 and paced at 1 Hz before (black) and after (red) treatment with cisapride (a), verapamil (b), quinidine (c) and quinine (d). (e) Percent change in APD₂₀ and (f) APD₉₀ for drugs treated with cisapride ( C), verapamil (V), quinidine (Qd), quinine (Qn) or a DMSO control solution (Ctrl). No drugs caused a significant change in APD₂₀ compared to control cells. Quinidine and quinine showed significant prolongation when compared to control cells. *P< 0.05, significantly different as indicated.