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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Curr Opin Chem Biol. 2022 Jun 29;70:102180. doi: 10.1016/j.cbpa.2022.102180

Figure 2.

Figure 2

Sequence map showing backbone cleavages caused by ECD (resulting in c/z fragment ions) and CAD (yielding b/y fragment ions) of bis-phosphorylated swine cTnI proteoform (with Met excision and N-terminal acetylation) and isotopic profiles of four c ions including c6 ion with acetylation, c21 with no phosphorylation, c22 with one phosphorylation, and c23 with two phosphorylations which localized phosphorylation sites at Ser22 and Ser 23. The red “p” represents phosphorylation; Ac, acetylation. Reproduced from [36].