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. 2022 Aug 9;92(4):532–544. doi: 10.1002/ana.26456

FIGURE 1.

FIGURE 1

HIV DNA persists in the CNS of people with HIV PWH despite long term suppression with ART. (A) HIV pol DNA copy number in human frontal lobe brain tissue from viremic (n = 18) or virally suppressed (n = 12) PWH or HIV‐uninfected individuals (n = 6) as measured by droplet digital PCR. (B) Correlative analysis of HIV pol DNA copy number in human brain tissue relative to HIV RNA copy number in cerebrospinal fluid or (C) plasma in untreated viremic PWH only (n = 18). Median and interquartile ranges shown; comparisons made using Mann–Whitney U tests. Correlative analyses assessed by non‐parametric Pearson's correlations with Pearson's rho and p values shown. The p < 0.05 considered statistically significant. Note: CSF viral load data unavailable for n = 4. ART = antiretroviral; CNS = central nervous system; ns = not significant; PCR = polymerase chain reaction; PWH = people with HIV; VS = virally suppressed.