FIGURE 4.

CNS reservoir size relative to lymphoid reservoirs in PWH. (A) Copy number (standardized to 10⁶ cells) or (B) frequency of proviral genomes measured by the IPDA from CNS frontal lobe tissue and matched lymphoid tissue (the spleen, lymph node, or gut) from viremic (n = 3, closed symbols) or virally suppressed PWH (n = 2, open symbols), where proviruses are defined as intact (ψ⁺ and env ⁺; orange), 3′ defective (ψ ⁺; blue), or 5′ defective (env ⁺, green). Median and interquartile ranges shown; comparisons made using paired Wilcoxon tests, p < 0.05 statistically significant. CNS = central nervous system; IPDA = intact proviral DNA assay; PWH = people with HIV.